Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.005
Abstract: In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage… read more here.
Keywords: translationally modified; product discovery; post translationally; ribosomally synthesized ... See more keywords
Natural product discovery through microbial genome mining.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.07.010
Abstract: The advent of the genomic era has opened up enormous possibilities for the discovery of new natural products. Also known as specialized metabolites, these compounds produced by bacteria, fungi, and plants have long been sought… read more here.
Keywords: product discovery; biology; natural product; genome mining ... See more keywords
Tapping Into Actinobacterial Genomes for Natural Product Discovery
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.655620
Abstract: The presence of secondary metabolite biosynthetic gene clusters (BGCs) makes actinobacteria well-known producers of diverse metabolites. These ubiquitous microbes are extensively exploited for their ability to synthesize diverse secondary metabolites. The extent of their ability… read more here.
Keywords: genomes natural; product discovery; tapping actinobacterial; actinobacterial genomes ... See more keywords
The use of nitrogen-15 in microbial natural product discovery and biosynthetic characterization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1174591
Abstract: This mini-review covers the use of nitrogen-15 in bacterial and fungal natural product discovery and biosynthetic characterization from 1970 to 2022. Nitrogen is an important element in a number of bioactive and structurally intriguing natural… read more here.
Keywords: use nitrogen; product discovery; discovery biosynthetic; natural product ... See more keywords
Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics
Sign Up to like & getrecommendations! Published in 2018 at "Marine Drugs"
DOI: 10.3390/md16090303
Abstract: Over the last two decades, halophilic (organisms that thrive at high salt concentrations) and halotolerant (organisms that have adapted to high salt concentrations) myxobacteria emerged as an important source of structurally diverse secondary metabolites from… read more here.
Keywords: directions marine; product discovery; myxobacterial natural; natural product ... See more keywords