Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "ChemistryOpen"
DOI: 10.1002/open.202200266
Abstract: Abstract The indole scaffold is a recurring structure in multiple bioactive heterocycles and natural products. Substituted indoles like the amino acid tryptophan serve as a precursor for a wide range of natural products with pharmaceutical… read more here.
Keywords: production; production halogenated; tryptophan tryptamine; halogenated tryptophan ... See more keywords
Metabolic engineering of Corynebacterium glutamicum for the fermentative production of halogenated tryptophan.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.12.008
Abstract: Halogenated compounds, like 7-chloro-l-tryptophan, are important intermediates or components of bioactive substances relevant for the pharmaceutical, chemical and agrochemical industries. About 20% of all pharmaceutical small molecule drugs and around 30% of all active compounds… read more here.
Keywords: production; metabolic engineering; tryptophan; glutamicum ... See more keywords