Enzymatic Production of Opine‐Type Chiral Amines with Controlled Stereoselectivity
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DOI: 10.1002/cctc.202402066
Abstract: Chiral secondary amine dicarboxylic acid derivatives are key building blocks of several peptidomimetic angiotensin‐converting enzyme (ACE2) inhibitors. Reductive amination of α‐keto acids with α‐amino esters can yield orthogonally functionalized derivatives facilitating further chemical modifications. Biocatalysis… read more here.
Keywords: production opine; enzymatic production; keto acids; amino esters ... See more keywords