A Facile Total Synthesis of Kilogram-Scale Production of SKLB1039: A Novel and Selective Hexahydroisoquinolin-Containing EZH2 Inhibitor.
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DOI: 10.2174/1570179419666220107161257
Abstract: BACKGROUND SKLB1039 is a potent, highly selective, and orally bioavailable EZH2 inhibitor, which significantly inhibited breast tumor growth and metastasis, in pre-clinical studies. In a previously reported synthesis of SKLB1039, the yields of several steps… read more here.
Keywords: ezh2 inhibitor; sklb1039; scale; production sklb1039 ... See more keywords