Integrator is a genome-wide attenuator of non-productive transcription.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.12.014
Abstract: Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act at the ends of protein-coding and small nuclear RNA (snRNA)… read more here.
Keywords: genome wide; transcription; int; non productive ... See more keywords
The RNA-binding protein RBP33 dampens non-productive transcription in trypanosomes
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1123
Abstract: Abstract In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts that are produced from… read more here.
Keywords: rbp33; productive transcription; rbp33 dampens; transcription ... See more keywords