Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2043845
Abstract: ABSTRACT Introduction The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.… read more here.
Keywords: products novel; kinase inhibitors; natural products; scaffolds design ... See more keywords
Abstract LB-B28: Abietane natural products as novel therapeutics against solid tumors
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DOI: 10.1158/1535-7163.targ-17-lb-b28
Abstract: Dysregulation of protein synthesis can lead to aberrant cellular proliferation and survival, a hallmark of cancer. Protein synthesis is a multistep process tightly controlled by specific translation factors. In eukaryotes, at the initiation point, the… read more here.
Keywords: solid tumors; natural products; abietane natural; breast cancer ... See more keywords
Valorization of Winemaking By-Products as a Novel Source of Antibacterial Properties: New Strategies to Fight Antibiotic Resistance
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082331
Abstract: The emergence of antibiotic-resistance in bacteria has limited the ability to treat bacterial infections, besides increasing their morbidity and mortality at the global scale. The need for alternative solutions to deal with this problem is… read more here.
Keywords: novel source; valorization winemaking; resistance; antibiotic resistance ... See more keywords