A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
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DOI: 10.1016/j.ejmech.2018.08.092
Abstract: Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid β peptides (Aβ) is central to Alzheimer's disease (AD) etiology. Aβ peptides are produced by sequential cleavage of APP by β-secretase… read more here.
Keywords: precursor protein; indirect secretase; profile indirect; new profile ... See more keywords