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   Articles with "profilin" as a keyword



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Computational modeling highlights the role of the disordered Formin Homology 1 domain in profilin‐actin transfer

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recommendations! Published in 2018 at "FEBS Letters"

DOI: 10.1002/1873-3468.13088

Abstract: Formins accelerate actin polymerization, assumed to occur through flexible Formin Homology 1 (FH1) domain‐mediated transfer of profilin‐actin to the barbed end. To study FH1 properties and address sequence effects, including varying length/distribution of profilin‐binding proline‐rich… read more here.

Keywords: profilin; formin homology; profilin actin; transfer ... See more keywords

Toxoplasma gondii profilin and tachyzoites RH strain may manipulate autophagy via downregulating Atg5 and Atg12 and upregulating Atg7.

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recommendations! Published in 2021 at "Molecular biology reports"

DOI: 10.1007/s11033-021-06667-5

Abstract: BACKGROUND Autophagy process is an important defense mechanism against intracellular infection. This process plays a critical role in limiting the development of Toxoplasma gondii. This study aimed to investigate the effects of T. gondii profilin… read more here.

Keywords: profilin tachyzoites; gondii profilin; fold value; profilin ... See more keywords
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Characterization of Profilin Binding Kinetics using Ensemble Molecular Dynamics Simulations

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1554

Abstract: We investigate the dynamics of profilin binding, including differences in binding for the loading and recruiting subregions of VASP, the effect of binding site mutations on peptide affinity for profilin, and the effect of actin… read more here.

Keywords: ensemble molecular; profilin; molecular dynamics; profilin binding ... See more keywords

Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization.

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recommendations! Published in 2017 at "Biophysical journal"

DOI: 10.1016/j.bpj.2017.06.012

Abstract: Formins are force-sensing proteins that regulate actin polymerization dynamics. Here, we applied stretching tension to individual actin filaments under the regulation of formin mDia1 to investigate the mechanical responses in actin polymerization dynamics. We found… read more here.

Keywords: profilin; actin; actin polymerization; effect ... See more keywords
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Actin Cytoskeleton: Profilin Gives Cells an Edge

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recommendations! Published in 2020 at "Current Biology"

DOI: 10.1016/j.cub.2020.05.041

Abstract: A new study reports that the actin-monomer-binding protein profilin 1 dictates protrusion character at the cell edge. These findings help explain how distinct, tunable actin polymerization pathways collaborate to form higher-order cellular structures. read more here.

Keywords: actin cytoskeleton; profilin; edge; profilin gives ... See more keywords

Synergistic effect of GRA7 and profilin proteins in vaccination against chronic Toxoplasma gondii infection.

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recommendations! Published in 2021 at "Vaccine"

DOI: 10.1016/j.vaccine.2020.12.072

Abstract: Toxoplasmosis is a zoonotic disease with worldwide prevalence in humans and warm-blooded animal populations. In livestock Toxoplasma gondii is the causal agent of significant economic losses since it can cause abortions in goats and sheep.… read more here.

Keywords: gondii infection; profilin; gra7; gondii ... See more keywords
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Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy.

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recommendations! Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.6b01263

Abstract: Protein oligomerization in the cell has important implications for both health and disease, and an understanding of the mechanisms by which proteins can self-associate is, therefore, of critical interest. Initial stages of the oligomerization process… read more here.

Keywords: nuclear magnetic; profilin; human profilin; magnetic resonance ... See more keywords

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells.

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recommendations! Published in 2022 at "Nature communications"

DOI: 10.1038/s41467-022-29660-3

Abstract: The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system development. However, how ubiquitination and NEDD4 control NCC development remains unknown. Here we combine… read more here.

Keywords: ubiquitinome profiling; profilin; global ubiquitinome; crest ... See more keywords

Cloning of nf-profilin and intercellular interaction with nf-actin in Naegleria fowleri cysts

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-90222-w

Abstract: Naegleria fowleri is a free-living amoeba found in lakes, soil, hot springs, and poorly chlorinated swimming pools. It is pathogenic to humans, causing a rare and fatal brain infection known as primary amoebic meningoencephalitis (PAM).… read more here.

Keywords: cloning profilin; naegleria fowleri; fowleri cysts; profilin ... See more keywords

Visualizing molecules of functional human profilin

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2021.09.01.458557

Abstract: Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and morphology of cells. Unfortunately, conventional fusion and direct labeling strategies… read more here.

Keywords: molecules functional; biochemical assays; pfn1; visualizing molecules ... See more keywords

Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline

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recommendations! Published in 2025 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-025-03588-z

Abstract: Profilin 1 (Pfn1) expression decreases significantly in aged human microglia, suggesting that loss of cytoskeletal integrity may trigger microglial senescence and increased synaptic vulnerability. To test this hypothesis, we used an inducible, microglia-specific Pfn1 knockout… read more here.

Keywords: senescence; cytoskeleton; profilin; checkpoint ... See more keywords