Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203410119
Abstract: Significance Interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs) is the key mediator for tumor cell recognition by cytotoxic T cells. We performed a multimodal analysis on a prostate tissue antigen, PAP,… read more here.
Keywords: silico immunopeptidomic; cancer; immunopeptidomic profiling; physical silico ... See more keywords
Abstract 143: A platform for deep evolutionary profiling of cancer resistance
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-143
Abstract: Despite the introduction of a number of new therapeutic classes including targeted inhibitors, immunotherapy, and antibody-drug conjugates, the ability to achieve long-term disease control in the majority of patients with advanced cancer remains elusive due… read more here.
Keywords: cancer; resistance; cancer resistance; platform deep ... See more keywords
Profiling Cancer-Associated Fibroblasts in Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147255
Abstract: Solid tumors are complex systems characterized by dynamic interactions between neoplastic cells, non-tumoral cells, and extracellular components. Among all the stromal cells that populate tumor microenvironment, fibroblasts are the most abundant elements and are critically… read more here.
Keywords: cancer associated; fibroblasts melanoma; associated fibroblasts; profiling cancer ... See more keywords