High Sensitivity Profiling of Chromatin Structure by MNase-SSP
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.02.007
Abstract: SUMMARY A complete view of eukaryotic gene regulation requires that we accurately delineate how transcription factors (TFs) and nucleosomes are arranged along linear DNA in a sensitive, unbiased manner. Here we introduce MNase-SSP, a single-stranded… read more here.
Keywords: sensitivity profiling; mnase ssp; profiling chromatin; high sensitivity ... See more keywords
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Sign Up to like & getrecommendations! Published in 2024 at "Nature Biotechnology"
DOI: 10.1038/s41587-024-02447-1
Abstract: Current methods for analyzing chromatin architecture are not readily scalable to heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial microfluidic device for high-throughput, single-cell chromatin conformation profiling in droplets. Using Droplet Hi-C,… read more here.
Keywords: architecture; chromatin architecture; profiling chromatin; single cell ... See more keywords