Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
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DOI: 10.1016/j.chembiol.2019.05.005
Abstract: The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, it is often unclear whether therapeutics with the same nominal targets… read more here.
Keywords: establishes polypharmacology; fda approved; polypharmacology fda; profiling establishes ... See more keywords