Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose
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DOI: 10.1186/s40364-018-0136-9
Abstract: BackgroundFor glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found… read more here.
Keywords: glioblastoma cells; profiling glioblastoma; restricted glucose; kinomic profiling ... See more keywords
Bioenergetic Profiling in Glioblastoma Multiforme Patients with Different Clinical Outcomes
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DOI: 10.3390/metabo13030362
Abstract: The accumulation of cell biomass is associated with dramatically increased bioenergetic and biosynthetic demand. Metabolic reprogramming, once thought as an epiphenomenon, currently relates to disease progression, also in response to extracellular fate-decisive signals. Glioblastoma multiforme… read more here.
Keywords: profiling glioblastoma; multiforme patients; bioenergetic profiling; patients different ... See more keywords