Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.
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DOI: 10.1021/acs.jmedchem.1c02228
Abstract: Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of hematological malignancies. Here, we report the design, synthesis, and profiling of new DOT1L inhibitors based on nonroutine carbocyclic C-nucleoside scaffolds. The experimentally observed… read more here.
Keywords: inhibitors methyltransferase; profiling highly; selective inhibitors; methyltransferase dot1l ... See more keywords