Transcriptomic Profiling in Human Decidua of Severe Preeclampsia Detected by RNA Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26221
Abstract: Maternal decidua plays a critical role in implantation and placentation. Impaired decidualization causes failed intravascular trophoblast invasion and inadequate placentation and then increases the risk of preeclampsia (PE). RNA sequencing (RNA‐Seq) has achieved great advances… read more here.
Keywords: transcriptomic profiling; human decidua; decidua; rna sequencing ... See more keywords
Profiling the Human Oral Mycobiome in Tissue and Saliva Using ITS2 DNA Metabarcoding Compared to a Fungal-Specific Database.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1518-8_15
Abstract: The advent of high-throughput sequencing has caused a paradigm shift from the one-pathogen one-disease model to the significance of dysbiosis of the oral microbiome, including the oral mycobiome. The oral mycobiome can be profiled by… read more here.
Keywords: oral mycobiome; mycobiome; mycobiome tissue; profiling human ... See more keywords
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05159-8
Abstract: Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points… read more here.
Keywords: human phenotypes; functional profiling; physiology; molecular functional ... See more keywords
Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.12.005
Abstract: To understand how glia may be altered in frontotemporal degeneration with tau pathology (FTD-tau), we used a NanoString glial profiling panel to measure 770 transcripts related to glial biology in human control (n = 8), Alzheimer's disease… read more here.
Keywords: glial profiling; ftd tau; frontotemporal degeneration; profiling human ... See more keywords
Gene expression profiling in the human alcoholic brain
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.02.017
Abstract: Long-term alcohol use causes widespread changes in gene expression in the human brain. Aberrant gene expression changes likely contribute to the progression from occasional alcohol use to alcohol use disorder (including alcohol dependence). Transcriptome studies… read more here.
Keywords: alcohol; gene expression; gene; brain ... See more keywords
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00137
Abstract: FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven… read more here.
Keywords: binding proteins; chemogenomic profiling; fk506 binding; profiling human ... See more keywords
Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Food Quality"
DOI: 10.1155/2018/5607641
Abstract: Increasing evidence suggests that Enterococcus faecalis strains can pass through placental barriers and cause adverse outcomes during pregnancy. However, the underlying molecular mechanism of the interaction between E. faecalis and the host placental barrier has… read more here.
Keywords: response; transcriptomic profiling; infection; enterococcus faecalis ... See more keywords
Transcriptome Profiling in Human Diseases: New Advances and Perspectives
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18081652
Abstract: In the last decades, transcriptome profiling has been one of the most utilized approaches to investigate human diseases at the molecular level. Through expression studies, many molecular biomarkers and therapeutic targets have been found for… read more here.
Keywords: new advances; human diseases; diseases new; rna sequencing ... See more keywords