Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.08.016
Abstract: Summary We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex and TeSR-E8 media. Analysis of transcriptome of single cells revealed similar expression of core pluripotency genes,… read more here.
Keywords: single cell; profiling identifies; key pathways; identifies key ... See more keywords
Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0824-4
Abstract: Fra-1, a member of the activator protein 1 (AP-1) family, is overexpressed in triple-negative breast cancer (TNBC) and plays crucial roles in tumor growth. Here we report the identification of 118 proteins interacting with endogenous… read more here.
Keywords: interaction profiling; identifies ddx5; profiling identifies; ddx5 oncogenic ... See more keywords
Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29660-3
Abstract: The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system development. However, how ubiquitination and NEDD4 control NCC development remains unknown. Here we combine… read more here.
Keywords: ubiquitinome profiling; profilin; global ubiquitinome; crest ... See more keywords
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007536
Abstract: Key Points • Cell of origin is stable between diagnosis and relapse.• A 30-gene panel of relapse-associated genes was able to stratify ABC patient survival at diagnosis. read more here.
Keywords: poor risk; identifies poor; profiling identifies; risk subset ... See more keywords
MicroRNA profiling identifies a novel compound with antidepressant properties
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0221163
Abstract: Patients with traumatic brain injury (TBI) are frequently diagnosed with depression. Together, these two leading causes of death and disability significantly contribute to the global burden of healthcare costs. However, there are no drug treatments… read more here.
Keywords: antidepressant properties; depression; profiling identifies; antidepressant ... See more keywords
Genome-Wide Integrative Transcriptional Profiling Identifies Age-Associated Signatures in Dogs
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061131
Abstract: Mammals experience similar stages of embryonic development, birth, infancy, youth, adolescence, maturity, and senescence. While embryonic developmental processes have been extensively researched, many molecular mechanisms regulating the different life stages after birth, such as aging,… read more here.
Keywords: genome wide; wide integrative; transcriptional profiling; age ... See more keywords