Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing
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DOI: 10.1002/cbic.201800235
Abstract: Drugs that covalently modify DNA are components of most chemotherapy regimens, often serving as first‐line treatments. Classically, the reactivity and selectivity of DNA alkylating agents has been determined in vitro with short oligonucleotides. A statistically… read more here.
Keywords: agents rna; profiling nucleobase; alkylating agents; structure ... See more keywords