Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in Streptomyces hygrospinosus var. Beijingensis
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11111463
Abstract: Two new cyclodipeptide (CDP) derivatives (1–2) and another seven known cyclodipeptides (3–9) were isolated from Streptomyces 26D9-414 by the genome mining approach combined with genetic dereplication and the “one strain many compounds” (OSMAC) strategy. The… read more here.
Keywords: reveal cytotoxic; profiling reveal; genome mining; cytotoxic cyclodipeptides ... See more keywords
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.62585
Abstract: Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels in genetically diverse mice at… read more here.
Keywords: proteomic transcriptomic; mrna protein; transcriptomic profiling; aging kidney ... See more keywords
Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.65417
Abstract: Vesicular neurotransmitter transporters (VNTs) mediate the selective uptake and enrichment of small-molecule neurotransmitters into synaptic vesicles (SVs) and are therefore a major determinant of the synaptic output of specific neurons. To identify novel VNTs expressed… read more here.
Keywords: proteomics metabolite; udp glucose; profiling reveal; localization proteomics ... See more keywords