Transcriptional profiling reveals protective mechanisms in brains of long-lived mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.12.016
Abstract: The brain plays a central role in organismal aging but is itself most sensitive to aging-related functional impairments and pathologies. Insights into processes underlying brain aging are the basis to positively impact brain health. Using… read more here.
Keywords: transcriptional profiling; profiling reveals; reveals protective; protective mechanisms ... See more keywords
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.11.008
Abstract: The emergence of SARS-CoV-2 virus has resulted in a worldwide pandemic, but effective antiviral therapies are not widely available. To improve treatment options, we conducted a high-throughput screen to uncover compounds that block SARS-CoV-2 infection.… read more here.
Keywords: profiling; sars cov; pharmacologic profiling; reveals lapatinib ... See more keywords
Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09107-y
Abstract: Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and protein solubility… read more here.
Keywords: atp; profiling reveals; proteome wide; solubility ... See more keywords
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26075-4
Abstract: The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However,… read more here.
Keywords: profiling reveals; protein interactors; reveals protein; proteomic profiling ... See more keywords
Salivary microbiome profiling reveals a dysbiotic schizophrenia-associated microbiota
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-021-00180-1
Abstract: Schizophrenia is a debilitating mental disorder and often has a prodromal period, referred to as clinical high risk (CHR) for psychosis, prior to the first episode. The etiology and pathogenesis of schizophrenia remain unclear. Despite… read more here.
Keywords: schizophrenia; profiling reveals; microbiome; salivary microbiome ... See more keywords
Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04189-4
Abstract: Patients with pneumonia and parapneumonic effusion (PPE) have elevated mortality and a poor prognosis. The aim of this study was to discover novel biomarkers to help distinguish between uncomplicated PPE (UPPE) and complicated PPE (CPPE).… read more here.
Keywords: reveals novel; profiling reveals; identify complicated; biomarkers identify ... See more keywords
Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic, and type 2 diabetic individuals
Sign Up to like & getrecommendations! Published in 2017 at "GigaScience"
DOI: 10.1093/gigascience/gix036
Abstract: Abstract The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be… read more here.
Keywords: reveals distinct; profiling reveals; distinct differences; plasma lipid ... See more keywords
Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasion
Sign Up to like & getrecommendations! Published in 2017 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12467
Abstract: Curcumin (diferuloylmethane) has chemopreventive and therapeutic properties against many types of tumors, both in vitro and in vivo. Previous reports have shown that curcumin exhibits anti‐invasive activities, but the mechanisms remain largely unclear. read more here.
Keywords: expression profiling; profiling reveals; gene expression; microrna gene ... See more keywords
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15900
Abstract: β‐Adrenoceptor agonists relieve airflow obstruction by activating β2‐adrenoceptors, which are G protein‐coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β‐adrenoceptor agonists are balanced agonists, however, and signal through both… read more here.
Keywords: adrenoceptor agonist; agonist profiling; profiling reveals; asthma ... See more keywords
Transcriptional profiling reveals mechanisms of sexually dimorphic responses of Populus cathayana to potassium deficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Physiologia plantarum"
DOI: 10.1111/ppl.12636
Abstract: Potassium (K) deficiency causes a series of physiological and metabolic disorders in plants, and dioecious species exhibit different responses based on sex. Our previous morphological and physiological observations indicated that Populus cathayana males were more… read more here.
Keywords: transcriptional profiling; profiling reveals; potassium deficiency; deficiency ... See more keywords
Metatranscriptomic profiling reveals diverse tick‐borne bacteria, protozoans and viruses in ticks and wildlife from Australia
Sign Up to like & getrecommendations! Published in 2022 at "Transboundary and Emerging Diseases"
DOI: 10.1111/tbed.14581
Abstract: Abstract Tick‐borne zoonoses are emerging globally due to changes in climate and land use. While the zoonotic threats associated with ticks are well studied elsewhere, in Australia, the diversity of potentially zoonotic agents carried by… read more here.
Keywords: profiling reveals; metatranscriptomic profiling; borne microorganisms; ticks wildlife ... See more keywords