Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential
Sign Up to like & getrecommendations! Published in 2025 at "Developmental Neurobiology"
DOI: 10.1002/dneu.23017
Abstract: ABSTRACT Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or… read more here.
Keywords: male female; learning potential; reveals distinct; chromatin profiling ... See more keywords
Transcriptomic Profiling Reveals 17β‐Estradiol Treatment Represses Ubiquitin‐Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13698
Abstract: With a decline of 17β‐estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female… read more here.
Keywords: skeletal muscle; treatment; ovariectomized mice; muscle ... See more keywords
Transcriptional profiling reveals protective mechanisms in brains of long-lived mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.12.016
Abstract: The brain plays a central role in organismal aging but is itself most sensitive to aging-related functional impairments and pathologies. Insights into processes underlying brain aging are the basis to positively impact brain health. Using… read more here.
Keywords: transcriptional profiling; profiling reveals; reveals protective; protective mechanisms ... See more keywords
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.11.008
Abstract: The emergence of SARS-CoV-2 virus has resulted in a worldwide pandemic, but effective antiviral therapies are not widely available. To improve treatment options, we conducted a high-throughput screen to uncover compounds that block SARS-CoV-2 infection.… read more here.
Keywords: profiling; sars cov; pharmacologic profiling; reveals lapatinib ... See more keywords
Exoproteome Profiling Reveals Increased Secretion of Adhesins and Proteases by Leptospira interrogans to Facilitate Host Colonization and Immune Modulation
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c10983
Abstract: Leptospirosis, a re-emerging zoonotic disease, is challenging human and animal health due to the lack of early and rapid diagnostic tools and effective vaccines. The exoproteome of the pathogen Leptospira interrogans expressed under pathogenic conditions… read more here.
Keywords: leptospira interrogans; host; reveals increased; secretion ... See more keywords
Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03607-w
Abstract: Autism Spectrum Disorder (ASD) affects 1 percent of the world’s population with an increased prevalence of 178 percent since 2000. Although altered synaptic function putatively accounts for many of the abnormalities seen in ASD, the… read more here.
Keywords: patient derived; extracellular vesicle; reveals novel; vesicle profiling ... See more keywords
Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09107-y
Abstract: Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and protein solubility… read more here.
Keywords: atp; profiling reveals; proteome wide; solubility ... See more keywords
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26075-4
Abstract: The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However,… read more here.
Keywords: profiling reveals; protein interactors; reveals protein; proteomic profiling ... See more keywords
Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46181-3
Abstract: In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple organs. However, our knowledge regarding… read more here.
Keywords: human parathyroids; reveals key; parathyroid glands; parathyroid ... See more keywords
Salivary microbiome profiling reveals a dysbiotic schizophrenia-associated microbiota
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-021-00180-1
Abstract: Schizophrenia is a debilitating mental disorder and often has a prodromal period, referred to as clinical high risk (CHR) for psychosis, prior to the first episode. The etiology and pathogenesis of schizophrenia remain unclear. Despite… read more here.
Keywords: schizophrenia; profiling reveals; microbiome; salivary microbiome ... See more keywords
Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04189-4
Abstract: Patients with pneumonia and parapneumonic effusion (PPE) have elevated mortality and a poor prognosis. The aim of this study was to discover novel biomarkers to help distinguish between uncomplicated PPE (UPPE) and complicated PPE (CPPE).… read more here.
Keywords: reveals novel; profiling reveals; identify complicated; biomarkers identify ... See more keywords