Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21968
Abstract: Necroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are involved in the pathway. Targeting the kinase domains of RIPK1 and/or 3 is a… read more here.
Keywords: necroptosis; kinase ligand; kinase domains; kinase ... See more keywords
Simultaneous Multiparameter Cellular Energy Metabolism Profiling of Small Populations of Cells
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DOI: 10.1038/s41598-018-22599-w
Abstract: Functional and genomic heterogeneity of individual cells are central players in a broad spectrum of normal and disease states. Our knowledge about the role of cellular heterogeneity in tissue and organism function remains limited due… read more here.
Keywords: populations cells; energy metabolism; metabolism profiling; profiling small ... See more keywords
Genome-Wide Profiling of Small RNAs and Degradome Revealed Conserved Regulations of miRNAs on Auxin-Responsive Genes during Fruit Enlargement in Peaches
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DOI: 10.3390/ijms18122599
Abstract: Auxin has long been known as a critical phytohormone that regulates fruit development in plants. However, due to the lack of an enlarged ovary wall in the model plants Arabidopsis and rice, the molecular regulatory… read more here.
Keywords: genome wide; fruit; genes fruit; profiling small ... See more keywords