eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.11.491502
Abstract: Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring… read more here.
Keywords: uncovers enhancer; oesophageal adenocarcinoma; profiling uncovers; enhancer landscape ... See more keywords
Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223269
Abstract: Multisystem inflammatory syndrome in children (MISC) is a systemic inflammatory condition seen in children following SARSCoV2 infection or exposure. Symptoms are highly variable and include fever, diarrhoea, cardiogenic shock, respiratory compromise and Kawasaki disease (KD)like… read more here.
Keywords: deep immune; immune profiling; inflammatory syndrome; syndrome children ... See more keywords
Integrated Profiling Uncovers Lymphoma Immunoglobulin Neoantigens.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-067
Abstract: CD4+ T cells specific for immunoglobulin-derived neoantigens target autologous lymphoma cells. read more here.
Keywords: integrated profiling; lymphoma immunoglobulin; immunoglobulin neoantigens; uncovers lymphoma ... See more keywords
Single-Cell Profiling Uncovers the Roles of Endometrial Fibrosis and Microenvironmental Changes in Adenomyosis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s402734
Abstract: Purpose Adenomyosis (AM) is a common benign uterine disorder that has deleterious effects on women’s health. However, the pathogenesis of AM is not clearly understood. We aimed to investigate the pathophysiological changes and molecular mechanism… read more here.
Keywords: cell; cell types; cell profiling; single cell ... See more keywords
Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020485
Abstract: Harnessing the immune response to tumor antigens in the form of autoantibodies, which occurs early during tumor development, has relevance to the detection of cancer at early stages. We conducted an initial screen of antigens… read more here.
Keywords: response; proteome profiling; profiling uncovers; ovarian cancer ... See more keywords