Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2701
Abstract: T cell dysfunction in the tumor microenvironment (TME) is a hallmark of many cancers. Reinvigoration of T cell function by PD-1 checkpoint blockade can result in striking clinical responses, but is only effective in a… read more here.
Keywords: exhausted cd8; checkpoint blockade; tumor; progenitor exhausted ... See more keywords
Abstract 3220: PD-1 antibody-bound progenitor-exhausted CD8+T cells in lymph nodes enhance PD-1 blockade anti-tumor immunity in gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3220
Abstract: Progenitor-exhausted T (Tpex) cells, marked by TCF1 and PD-1 expression, are essential for the efficacy of immune checkpoint inhibitors (ICIs) like anti-PD-1 antibodies. These cells serve as precursors to intratumoral exhausted T (Tex) cells and… read more here.
Keywords: cancer; tumor; gastrointestinal cancer; tpex cells ... See more keywords
Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.583382
Abstract: Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for the immune populations that provide the best tumor control and that can be… read more here.
Keywords: anti immunotherapy; melanoma; cd8; immunotherapy ... See more keywords