Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis.
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DOI: 10.1016/j.molimm.2019.08.003
Abstract: Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that… read more here.
Keywords: progenitors clps; lymphoid progenitors; bone; common lymphoid ... See more keywords