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Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.02.011
Abstract: LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the nuclear periphery. Mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown. We report that…
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Keywords:
nuclear interior;
ps22 lamin;
progeria;
lamin binding ... See more keywords