Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape
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DOI: 10.1111/acel.12621
Abstract: Ideally, disease modeling using patient‐derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation.… read more here.
Keywords: reprogramming progeria; initiation progression; epigenetic landscape; landscape ... See more keywords