Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting β-catenin signal pathway in vitro
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DOI: 10.1007/s00441-018-2930-y
Abstract: Nuclear protein, lamin A, which is a component of inner membrane on nucleoplasm, plays a role in nuclear formation and cell differentiation. The expression of mutated lamin A, termed progerin, causes a rare genetic aging… read more here.
Keywords: progerin; lamin dc50; expression; differentiation ... See more keywords
Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation
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DOI: 10.1161/circulationaha.122.060002
Abstract: Background: Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare, fatal, premature aging disease caused by a toxic protein called progerin. Circulating progerin has not been previously detected, precluding research using readily available biological samples. This study… read more here.
Keywords: decrease; progerin; gilford progeria; plasma progerin ... See more keywords