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Progerin modulates the IGF-1R/Akt signaling involved in aging

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2 Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abo0322

Abstract: Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like… read more here.

Keywords: signaling involved; modulates igf; akt signaling; progerin modulates ... See more keywords