Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202502444
Abstract: As the global production of bisphenol analogs (BPs) surges to replace regulated bisphenol A (BPA), their pervasive environmental presence and uncharacterized breast cancer risk raise critical public health concerns. Herein, the environmental risks of BPs… read more here.
Keywords: cancer risk; breast cancer; risk; progesterone receptor ... See more keywords
Author response to: Comment on: Meta‐analysis of the impact of progesterone receptor status on oncological outcomes in oestrogen receptor‐positive breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Surgery"
DOI: 10.1002/bjs.11499
Abstract: *See Boland et al.1 for references. Hazard ratios are shown with 95 per cent confidence intervals. †Values in parentheses are standard errors. PgR–, progesterone receptor-negative; PgR+, progesterone receptor-positive; HER2–, HER2-negative; HER2+, HER2-positive. Author response to:… read more here.
Keywords: progesterone receptor; receptor positive; response comment; receptor ... See more keywords
Progesterone receptor expression in cajal‐retzius cells of the developing rat dentate gyrus: Potential role in hippocampus‐dependent memory
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24485
Abstract: The development of medial temporal lobe circuits is critical for subsequent learning and memory functions later in life. The present study reports the expression of progesterone receptor (PR), a powerful transcription factor of the nuclear… read more here.
Keywords: progesterone receptor; cajal retzius; retzius cells; dentate gyrus ... See more keywords
A mouse model engineered to conditionally express the progesterone receptor‐B isoform
Sign Up to like & getrecommendations! Published in 2018 at "genesis"
DOI: 10.1002/dvg.23223
Abstract: Using a Rosa26 gene targeting strategy in mouse embryonic stem cells, we have generated a new transgenic mouse (Pgr‐B LSL), which is designed to conditionally express the epitope‐tagged mouse progesterone receptor‐B (PGR‐B) isoform when crossed… read more here.
Keywords: progesterone receptor; pgr lsl; conditionally express; pgr ... See more keywords
Analysis of estrogen and progesterone receptor gene polymorphisms in leiomyoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22704
Abstract: Leiomyoma, one of the most common benign tumors, causes morbidity during the reproductive years in women. The molecular pathogenesis of the disease is not clear. Leiomyomas are hormone‐sensitive tumors affecting around 20%‐25% of women. Gene… read more here.
Keywords: gene; progesterone receptor; analysis estrogen;
Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.70121
Abstract: Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic β‐cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues… read more here.
Keywords: membrane component; receptor membrane; progesterone receptor; development ... See more keywords
Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0700-4
Abstract: PurposeVitamin D receptor (VDR) and progesterone receptor (PR) expression has been described in papillary thyroid carcinoma (PTC) but data regarding association with tumor histological characteristics and localization of the protein expression are scarce.Materials and methodsFormalin-fixed,… read more here.
Keywords: protein; progesterone receptor; expression; receptor ... See more keywords
Clinical Potential of Estrogen and Progesterone Receptor Imaging.
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DOI: 10.1016/j.cpet.2018.02.005
Abstract: Molecular imaging using 16α-[18F]fluoro-17β-estradiol (FES) and 18F-fluoro-furanyl-norprogesterone PET can assess in vivo function of steroid hormone receptors in breast cancer. These experimental agents have been tested in many single-center clinical trials and show promise to elucidate… read more here.
Keywords: progesterone receptor; clinical potential; estrogen progesterone; estrogen ... See more keywords
High expression of progesterone receptor may be an adverse prognostic factor in oestrogen receptor-negative/progesterone receptor-positive breast cancer: results of comprehensive re-evaluation of multi-institutional case series.
Sign Up to like & getrecommendations! Published in 2022 at "Pathology"
DOI: 10.1016/j.pathol.2021.10.003
Abstract: Oestrogen receptor (ER)-negative (-) progesterone receptor (PgR)-positive (+) is the least common combination of steroid receptor expression observed in breast cancer. There are many controversies regarding the actual existence of ER-/PgR+ phenotype. In the current… read more here.
Keywords: breast cancer; pgr; receptor; progesterone receptor ... See more keywords
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.023
Abstract: Graphical abstract Figure. No Caption available. Abstract A controversial relationship between sigma‐2 and progesterone receptor membrane component 1 (PGRMC1) proteins, both representing promising targets for the therapy and diagnosis of tumors, exists since 2011, when… read more here.
Keywords: pgrmc1; progesterone receptor; receptor membrane; sigma ... See more keywords
Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2017.12.015
Abstract: &NA; Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine‐dependent… read more here.
Keywords: revisiting progesterone; progesterone receptor; progesterone; breast cancer ... See more keywords