Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host
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DOI: 10.1002/adhm.202403802
Abstract: Maintaining stable drug concentrations in the bloodstream is a challenge for injectable hydrophobic progestin contraceptives. This work investigates porous silicon dioxide (pSiO2) microparticles as a delivery vehicle for progestins via melt‐infiltration of drugs into the… read more here.
Keywords: release; porous silicon; drug; seg ... See more keywords
Aripiprazole as an Inhibitor of the EGFR/PI3K/AKT Signaling Pathway and Sensitizer of MPA Suppressed Progestin‐Resistant Endometrial Cancer Cells
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70017
Abstract: Drug repurposing, which involves applying existing pharmaceuticals to new therapeutic areas, offers several advantages, including increased efficiency, reduced costs, and lower risks. The research aimed to investigate the molecular mechanisms underlying the new application of… read more here.
Keywords: progestin resistant; endometrial cancer; akt signaling; signaling pathway ... See more keywords
Evolution of the neurosurgical management of progestin‐associated meningiomas: a 23-year single‐center experience
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-021-03696-9
Abstract: The improving knowledge of interactions between meningiomas and progestin refines the management of this specific condition. We assessed the changes over time of the management of progestin-associated meningiomas. We retrospectively studied consecutive adult patients who… read more here.
Keywords: progestin associated; progestin; year; time ... See more keywords
Induction of sperm hypermotility through membrane progestin receptor alpha (mPRα): A teleost model of rapid, multifaceted, nongenomic progestin signaling.
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.12.002
Abstract: Rapid progestin effects on sperm physiology have been described in a variety of vertebrate species. Here, we briefly review the signaling pathways mediating rapid progestin induction of sperm hypermotility and increased fertility in two teleost… read more here.
Keywords: hypermotility; induction sperm; progestin; teleost ... See more keywords
EP645 Anti-estrogen treatment in endometrial cancer: a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.701
Abstract: Introduction/Background Hormonal therapy in endometrial cancer (EC) is used for patients who wish to preserve fertility and for patients with advanced or recurrent disease in a palliative setting. Since estrogen plays an important role in… read more here.
Keywords: anti estrogenic; treatment; anti estrogen; cancer ... See more keywords
Route-specific association of progestin therapy and concurrent metformin use in obese women with complex atypical hyperplasia
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2020-001362
Abstract: Introduction Previous studies have suggested that metformin use may enhance the therapeutic effect of progestin therapy for endometrial hyperplasia or malignancy. However, it is not known how the impact of concurrent metformin may be altered… read more here.
Keywords: concurrent metformin; intrauterine device; progestin; progestin therapy ... See more keywords
Abstract 1124: Discordance between gross and histologic findings in progestin-treated endometrial neoplasia
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1124
Abstract: Introduction: Hysterectomy with or without lymphadenectomy remains the first line of therapy for endometrial cancer (EC). Rising levels of obesity coupled with a trend toward delayed childbearing has led to an increasing population of young… read more here.
Keywords: histologic findings; progestin; progestin treated; gross histologic ... See more keywords
OR35-05 Effects of Hormonal Contraceptives on Brown Adipose Tissue Activity and Glucose Metabolism in Women of Reproductive Age
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.085
Abstract: Abstract Disclosure: A.D. De Jesus: None. A. Karagiannidis: None. P. Sridhar: None. M.A. Cowley: None. T. Mustafa: None. B.A. Henry: None. Introduction: It is estimated that Worldwide, over 200 million women use a hormonal contraceptive,… read more here.
Keywords: dose; none; hormonal contraceptives; high dose ... See more keywords
MON-196 Hormone Replacement Therapy In Menopausal Patient With Symptomatic Endometriosis And Bone Metabolism: A Case Report
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.1927
Abstract: Abstract Disclosure: I. Murta: None. J. Bicca: None. N. Cardoso: None. Background: Endometriosis is an estrogen-dependent clinical syndrome traditionally regarded as a premenopausal condition that tends to regress after menopause. Contrary to this assumption, it… read more here.
Keywords: hormone replacement; therapy; endometriosis; case ... See more keywords
Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0214152
Abstract: Progestin-only long-acting reversible contraceptives (LARCs) are increasingly popular among women seeking contraception; however, recent epidemiological studies suggest that systemically administered medroxyprogesterone acetate (MPA) may increase HIV acquisition. In order to determine the exact mechanisms underlying… read more here.
Keywords: progestin; delivery method; long acting; transmission ... See more keywords
Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s210228
Abstract: Purpose Dydrogesterone (DYG) has been demonstrated to be an alternative progestin in the progestin-primed ovarian stimulation (PPOS) protocol with comparable oocyte retrieval and pregnancy outcomes. However, its safety regarding neonatal outcomes and congenital malformations is… read more here.
Keywords: ovarian stimulation; congenital malformations; protocol; neonatal outcomes ... See more keywords