DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2317
Abstract: Progestin resistance limits the effectiveness of progestin therapy in endometrial carcinoma for patients who desire to preserve fertility. To investigate the molecular mechanism of progestin resistance in endometrial carcinoma, we performed microarray analysis among Ishikawa… read more here.
Keywords: dach1; progestin resistance; endometrial carcinoma; resistance ... See more keywords
The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.003
Abstract: Progestin resistance is a critical factor that prevents patients with endometrial cancer (EC) from receiving conservative therapy. However, the etiology remains elusive. Cancer stem cells (CSCs) may be a contributing factor to progestin resistance in… read more here.
Keywords: cancer; stem; progestin resistance; endometrial cancer ... See more keywords
PI3K/AKT/mTOR pathway promotes progestin resistance in endometrial cancer cells by inhibition of autophagy
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s95267
Abstract: Endometrial cancer (EC) is now one of the most common malignant tumors in young women. In all, 90% of young patients with EC have a high expression of progesterone recep tor, can be treated with… read more here.
Keywords: progestin resistance; endometrial cancer; mtor; progestin ... See more keywords
Progestin Resistance and Corresponding Management of Abnormal Endometrial Hyperplasia and Endometrial Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14246210
Abstract: Simple Summary Patients with endometrial hyperplasia (EH) and endometrial cancer (EC) often fail conservative treatment due to progestin resistance. This article reviews the therapeutic role of progestin in EH and EC as well as the… read more here.
Keywords: progestin resistance; resistance; endometrial hyperplasia; treatment ... See more keywords