The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.03.019
Abstract: The 2021 Gairdner Prize is awarded to Daniel Drucker, Joel Habener, and Jens Juul Holst for the discovery of novel peptides encoded in the proglucagon sequence and the establishment of their physiological roles. These discoveries… read more here.
Keywords: proglucagon derived; islet bridesmaid; bride proglucagon; bridesmaid becomes ... See more keywords
Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.08.009
Abstract: The importance of pancreatic versus intestinal-derived GLP-1 for glucose homeostasis is controversial. We detected active GLP-1 in the mouse and human pancreas, albeit at extremely low levels relative to glucagon. Accordingly, to elucidate the metabolic importance… read more here.
Keywords: glucose homeostasis; gut; glp; proglucagon derived ... See more keywords
Regulation of intestinal lipid and lipoprotein metabolism by the proglucagon-derived peptides glucagon like peptide 1 and glucagon like peptide 2
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000495
Abstract: Purpose of review The intestine is highly efficient at absorbing and packaging dietary lipids onto the structural protein apoB48 for distribution throughout the body. Here, we summarize recent advances into understanding the physiological and pharmacological… read more here.
Keywords: glucagon like; glp; proglucagon derived; derived peptides ... See more keywords
Effect of the glucagon‐like peptide‐1 analogue liraglutide versus placebo treatment on circulating proglucagon‐derived peptides that mediate improvements in body weight, insulin secretion and action: A randomized controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.1111/dom.14242
Abstract: To examine how circulating glucagon‐like peptide‐1 (GLP‐1) concentrations during liraglutide treatment relate to its therapeutic actions on glucose and weight, and to study the effects of liraglutide on other proglucagon‐derived peptides (PGDPs), including endogenous GLP‐1,… read more here.
Keywords: proglucagon derived; glucagon like; like peptide;
A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon‐derived peptide levels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13986
Abstract: Glucagon, a peptide hormone produced from proglucagon, is involved in the pathophysiology of diabetes. Plasma glucagon levels are currently measured by sandwich enzyme‐linked immunosorbent assay (ELISA), but the currently used sandwich ELISA cross‐reacts with proglucagon‐derived… read more here.
Keywords: used sandwich; sandwich elisa; currently used; glucagon ... See more keywords
Mutational Landscape of the Proglucagon-Derived Peptides
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.698511
Abstract: Strong efforts have been placed on understanding the physiological roles and therapeutic potential of the proglucagon peptide hormones including glucagon, GLP-1 and GLP-2. However, little is known about the extent and magnitude of variability in… read more here.
Keywords: mutational landscape; landscape proglucagon; glp; proglucagon derived ... See more keywords
High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14050975
Abstract: (1) Background: Protein stimulates the secretion of glucagon (GCG), which can affect glucose metabolism. This study aimed to analyze the metabolic effect of a high-protein diet (HPD) in the presence or absence of proglucagon-derived peptides,… read more here.
Keywords: hpd; derived peptides; high protein; proglucagon derived ... See more keywords