Immune microenvironment and prognostic genes of triple-negative breast cancer in the context of transcriptome and single-cell sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-15157-8
Abstract: Immune-related genes (IRGs) play a pivotal role in the tumor microenvironment of triple-negative breast cancer (TNBC). This study aimed to uncover novel prognostic markers for TNBC based on IRGs. Differential expression analysis, univariate Cox regression,… read more here.
Keywords: breast cancer; negative breast; triple negative; immune microenvironment ... See more keywords
Identification of prognostic genes associated with phase separation in lung adenocarcinoma and construction of prognostic models
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DOI: 10.1038/s41598-025-17884-4
Abstract: Lung adenocarcinoma (LUAD) is a common histological subtype of lung cancer, but its prognosis remains poor. Recent studies have suggested that liquid-liquid phase separation-related genes (LRGs) can significantly predict the prognosis of low-grade tumors. Identifying… read more here.
Keywords: lung adenocarcinoma; phase separation; risk; prognostic genes ... See more keywords
Integration of Single-cell and bulk RNA sequencing data uncovers lymphatic metastasis-related prognostic genes and a predictive model in bladder cancer
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DOI: 10.1038/s41598-025-22803-8
Abstract: Bladder cancer (BLCA) exhibits considerable heterogeneity, and research into its tumor microenvironment and prognostic biomarkers remains insufficient. This study aims to identify key prognostic genes and immune microenvironment factors to enhance clinical assessment. Primary tumor… read more here.
Keywords: single cell; rna sequencing; model; bladder cancer ... See more keywords
Data mining of immune-related prognostic genes in metastatic melanoma microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201704
Abstract: Abstract Skin cutaneous melanoma (SKCM) is one of the most deadly malignancies. Although immunotherapies showed the potential to improve the prognosis for metastatic melanoma patients, only a small group of patients can benefit from it.… read more here.
Keywords: metastatic melanoma; microenvironment; melanoma; prognostic genes ... See more keywords
Integrated Analysis of Multi-Omics Data to Identify Prognostic Genes for Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0878
Abstract: Pancreatic cancer (PC) is a common cause of cancer-related deaths. Current research shows that prognostic biomarkers play a key role in the treatment of PC. This study aimed to identify prognostic genes through bioinformatics research.… read more here.
Keywords: cancer; analysis; expression; prognostic genes ... See more keywords
Improved prediction of breast cancer outcome by identifying heterogeneous biomarkers
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx487
Abstract: Motivation Identification of genes that can be used to predict prognosis in patients with cancer is important in that it can lead to improved therapy, and can also promote our understanding of tumor progression on… read more here.
Keywords: prognostic genes; improved prediction; breast cancer; cancer ... See more keywords
Bioinformatics identification of key microRNA-correlated genes associated with hepatocellular carcinoma heterogeneity and prognosis
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DOI: 10.1186/s12876-025-04031-6
Abstract: Hepatocellular carcinoma (HCC) represents the most prevalent histological subtype of primary liver cancer. This study aimed to establish a miRNA-related prognostic genes signature, providing a theoretical framework for prognosis and therapy in patients with HCC.… read more here.
Keywords: carcinoma; hcc; risk; prognosis ... See more keywords
Exploring autophagy-related prognostic genes of Alzheimer’s disease based on pathway crosstalk analysis
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DOI: 10.17305/bjbms.2021.7019
Abstract: Recent studies have shown that different signaling pathways are involved in the pathogenesis of Alzheimer’s disease (AD), with complex molecular connections existing between these pathways. Autophagy is crucial for the degradation and production of pathogenic… read more here.
Keywords: prognostic genes; alzheimer disease; pathway crosstalk; analysis ... See more keywords
Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer
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DOI: 10.2147/jir.s357144
Abstract: Background The changes of lipid metabolism have been implicated in the development of many tumors, but its role in breast invasive carcinoma (BRCA) remains to be fully established. Here, we attempted to ascertain the prognostic… read more here.
Keywords: metabolism; prognostic genes; metabolism related; lipid metabolism ... See more keywords
Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets
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DOI: 10.2147/jir.s490457
Abstract: Purpose Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. PANoptosis, a unique inflammatory programmed cell death, it manifests as the simultaneous activation of signaling markers for pyroptosis, apoptosis, and necroptosis. However, research on… read more here.
Keywords: role panoptosis; idiopathic pulmonary; panoptosis; pulmonary fibrosis ... See more keywords
Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis
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DOI: 10.2147/ott.s528050
Abstract: Introduction Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide, characterized by complex pathogenesis and poor prognosis. Migrasomes, as newly discovered organelles, play crucial roles in tumor microenvironment modulation and immune… read more here.
Keywords: related prognostic; cancer; analysis; gastric cancer ... See more keywords