Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.110108
Abstract: Summary Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection. However, we demonstrate, in Sarm1 haploinsufficient… read more here.
Keywords: programmed axon; degeneration; axon degeneration; sarm1 levels ... See more keywords
What Is the Role of Mitochondrial Dysfunction in Programmed Axon Death?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200691
Abstract: Axonal loss occurs in many neurologic disorders and its prevention is a major target of disease-modifying therapies. Over the past several years, studies in the Wlds mutant mouse model characterized by delayed Wallerian degeneration (WD)… read more here.
Keywords: mitochondrial dysfunction; programmed axon; role mitochondrial; axon death ... See more keywords