Progranulin regulates neurogenesis in the developing vertebrate retina
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22499
Abstract: We evaluated the expression and function of the microglia‐specific growth factor, Progranulin‐a (Pgrn‐a) during developmental neurogenesis in the embryonic retina of zebrafish. At 24 hpf pgrn‐a is expressed throughout the forebrain, but by 48 hpf… read more here.
Keywords: cell; cell cycle; progranulin; pgrn ... See more keywords
Methods to Investigate the Roles of Progranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8559-3_22
Abstract: Endothelial cells activate the expression of progranulin during angiogenesis. Here we discuss methods to investigate progranulin activity on endothelial cells in vitro and on aortic explants. We then discuss methods to generate transgenic mice in… read more here.
Keywords: progranulin angiogenesis; progranulin; roles progranulin; methods investigate ... See more keywords
Methods for Expression and Purification of Biologically Active Recombinant Progranulin.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8559-3_3
Abstract: Purifying progranulin may be useful in a variety of situations, for example, after it has been mutated or otherwise modified or when working with a species for which commercially produced progranulin is unavailable. A method… read more here.
Keywords: progranulin; methods expression; biologically active; purification ... See more keywords
Progranulin Promotes Regeneration of Inflammatory Periodontal Bone Defect in Rats via Anti-inflammation, Osteoclastogenic Inhibition, and Osteogenic Promotion
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0886-4
Abstract: Progranulin (PGRN) has been proved to play a crucial role in anti-inflammation and osteogenesis promotion; thus, it was hypothesized that PGRN could promote bone regeneration in periodontal disease. In this experiment, the periodontal bone defects… read more here.
Keywords: group; periodontal bone; progranulin; bone ... See more keywords
Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.08.042
Abstract: BACKGROUND AND AIMS Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell-derived progranulin impacts atherosclerosis development. METHODS Ldlr-/- mice were transplanted with bone marrow… read more here.
Keywords: atherosclerosis progranulin; progranulin hematopoietic; progranulin; lesions mice ... See more keywords
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.07.004
Abstract: Mutations in GBA1, the gene encoding the lysosomal hydrolase glucocerebrosidase (GCase), are a risk factor for parkinsonism. Pursuing the potential mechanisms underlying this risk in aging neurons, we propose a new network uniting three major… read more here.
Keywords: pro cathepsin; prosaposin progranulin; cathepsin prosaposin; prosaposin ... See more keywords
Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.06.012
Abstract: Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-knockout mice display… read more here.
Keywords: cause; progranulin; lipofuscinosis; nes cko ... See more keywords
Adenoviral mediated expression of anti-inflammatory progranulin by placental explants modulates endothelial cell activation by decrease of ICAM-1 expression.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2019.12.018
Abstract: INTRODUCTION Functional disorders of the villous trophoblast may result in preeclampsia through the release of endothelial activating substances. Progranulin is an anti-inflammatory, pro-angiogenic cytokine with TNF-α antagonizing activity. The trophoblastic expression of progranulin is increased… read more here.
Keywords: anti inflammatory; endothelial cell; placental progranulin; progranulin ... See more keywords
Effects of progranulin on the pathological conditions in experimental myocardial infarction model
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68804-7
Abstract: Progranulin is a secreted growth factor associated with multiple physiological functions in ischemic pathophysiology. However, it is still not fully understood how progranulin is involved in ischemic lesion and cardiac remodeling after myocardial infarction (MI).… read more here.
Keywords: effects progranulin; myocardial infarction; progranulin; reperfusion ... See more keywords
Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2017 at "Brain"
DOI: 10.1093/brain/awx060
Abstract: Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by neurons and microglia, are a common autosomal dominant cause of frontotemporal dementia, a neurodegenerative disease commonly characterized by disrupted social and emotional behaviour. GRN mutations… read more here.
Keywords: neuronal progranulin; frontotemporal dementia; model frontotemporal; progranulin ... See more keywords
Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000168
Abstract: Objectives The identification of peripheral biomarkers for bipolar disorder is of great importance and has the potential to improve diagnosis, treatment and prognosis. Recent studies have reported lower plasma progranulin levels in bipolar individuals compared… read more here.
Keywords: serum progranulin; disorder; bipolar individuals; progranulin ... See more keywords