Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000168
Abstract: Objectives The identification of peripheral biomarkers for bipolar disorder is of great importance and has the potential to improve diagnosis, treatment and prognosis. Recent studies have reported lower plasma progranulin levels in bipolar individuals compared… read more here.
Keywords: serum progranulin; disorder; bipolar individuals; progranulin ... See more keywords
Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282822
Abstract: A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a… read more here.
Keywords: nonsense mediated; mouse; progranulin levels; progranulin ... See more keywords