Progranulin as a therapeutic target in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.11.015
Abstract: Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and… read more here.
Keywords: progranulin therapeutic; target neurodegenerative; pgrn; gene ... See more keywords
Progranulin as a therapeutic target for dementia
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1487951
Abstract: ABSTRACT Introduction: Progranulin (PGRN) is an acrosomal glycoprotein that is synthesized during spermatogenesis. It is overexpressed in tumors and has anti-inflammatory properties. The protein may be cleaved into granulins which display pro-inflammatory properties. In 2006,… read more here.
Keywords: progranulin therapeutic; target dementia; therapeutic target; pgrn ... See more keywords