Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.09.003
Abstract: Drug transporters play important roles in the elimination of various compounds from the blood. Genetic variation and drug-drug interactions underlie the pharmacokinetic differences for the substrates of drug transporters. Some endogenous substrates of drug transporters… read more here.
Keywords: progress identifying; drug; drug transporter; current progress ... See more keywords
Challenges and Progress in Identifying Cervical Spine Injuries in Children
Sign Up to like & getrecommendations! Published in 2019 at "Pediatrics"
DOI: 10.1542/peds.2018-4052
Abstract: * Abbreviations: CSI — : cervical spine injury NEXUS — : National Emergency X-Ray Utilization Study Over 8 million children are treated in the emergency department for traumatic injuries annually, many of whom undergo cervical… read more here.
Keywords: progress identifying; cervical spine; challenges progress; identifying cervical ... See more keywords
Recent progress in identifying genetic and epigenetic contributions to epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive and Developmental Medicine"
DOI: 10.4103/2096-2924.224912
Abstract: Epilepsy is a serious disorder of the central nervous system characterized by recurrent seizures. There are many known causes of epilepsy, including genetic factors, brain damage, and environmental factors, but the pathogenic mechanisms are largely… read more here.
Keywords: progress identifying; epigenetic contributions; inherited forms; genetic epigenetic ... See more keywords