WTAP Promotes Malignant Progression and Immune Escape of Glioblastoma by Regulating N6‐methyladenosine Modification of CENPF
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DOI: 10.1002/jbt.70523
Abstract: Glioblastoma (GBM) is a malignant tumor. It has been shown that centromere protein F (CENPF) may serve as a potential prognostic biomarker for glioma patients, while Wilms' tumor 1‐associating protein (WTAP) is frequently upregulated across… read more here.
Keywords: cenpf; immune escape; gbm; progression immune ... See more keywords
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients
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DOI: 10.1038/s41420-020-00376-x
Abstract: COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes pandemic control and strategy difficult; optimizing management requires a systems biology approach of understanding the disease. Here we sought to potentially understand and infer… read more here.
Keywords: coronavirus infected; disease; infected patients; disease progression ... See more keywords
CD73 acts as a prognostic biomarker and promotes progression and immune escape in pancreatic cancer
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DOI: 10.1111/jcmm.15500
Abstract: CD73 is a glycosylphosphatidylinositol (GPI)‐anchored protein that attenuates tumour immunity via cooperating with CD39 to generate immunosuppressive adenosine. Therefore, CD73 blockade has been incorporated into clinical trials for cancers based on preclinical efficacy. However, the… read more here.
Keywords: pancreatic cancer; cd73; expression; cancer ... See more keywords
Cytokine signatures predict response, progression, and immune-related toxicity in Sézary syndrome patients treated with mogamulizumab
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DOI: 10.1182/blood-2025-5430
Abstract: Introduction Sézary syndrome is a rare, aggressive cutaneous T-cell lymphoma characterized by erythroderma, lymphadenopathy, and malignant T-cells in peripheral blood. Mogamulizumab, a humanized anti-CCR4 monoclonal antibody, has demonstrated clinical efficacy in this setting. However, the… read more here.
Keywords: progression; response; progression immune; cytokine ... See more keywords
Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment
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DOI: 10.3389/fimmu.2025.1526296
Abstract: Background Glioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms and T cell exhaustion, yet these remain understudied. Methods Key genes were identified using Lasso regression, followed… read more here.
Keywords: disulfidptosis tex; glioblastoma progression; disulfidptosis; cell ... See more keywords
Role of Androgen Receptor in Melanoma: Mechanisms of Tumor Progression, Immune Evasion, and Therapeutic Implications
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DOI: 10.3390/cancers17172828
Abstract: Simple Summary This review explains how the androgen receptor (AR), a protein typically associated with prostate cancer, also has a significant role in melanoma, one of the most aggressive skin cancers. Metastasis (spread): AR activates… read more here.
Keywords: role; melanoma; progression immune; androgen receptor ... See more keywords