Opportunities and Challenges of Disease Progression Modeling in Drug Development - An IQ Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2873
Abstract: Disease progression modeling (DPM) represents an important model-informed drug development framework. The scientific communities support the use of DPM to accelerate and increase efficiency in drug development. This article summarizes International Consortium for Innovation &… read more here.
Keywords: progression modeling; development; drug development; disease progression ... See more keywords
Multivariate disease progression modeling with longitudinal ordinal data.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9770
Abstract: Disease modeling is an essential tool to describe disease progression and its heterogeneity across patients. Usual approaches use continuous data such as biomarkers to assess progression. Nevertheless, categorical or ordinal data such as item responses… read more here.
Keywords: multivariate disease; ordinal data; disease; progression ... See more keywords
Training recurrent neural networks robust to incomplete data: Application to Alzheimer’s disease progression modeling
Sign Up to like & getrecommendations! Published in 2019 at "Medical Image Analysis"
DOI: 10.1016/j.media.2019.01.004
Abstract: HighlightsWe propose a generalized algorithm to train LSTM networks robust to incomplete data.We introduce an end‐to‐end approach for biomarker modeling and clinical status prediction.It is applied to model Alzheimer’s disease progression using volumetric MRI biomarkers.Our… read more here.
Keywords: alzheimer disease; progression; disease; disease progression ... See more keywords