Over-expressed RHEB promotes the progression of pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119462
Abstract: AIMS Mammalian/mechanistic target of rapamycin (mTOR) is essential in the progression of pancreatic adenocarcinoma (PAAD). But the role of Ras homolog enriched in brain (RHEB), a key activator of mTORC1, is unclear in this disease.… read more here.
Keywords: paad; pancreatic adenocarcinoma; expressed rheb; rheb ... See more keywords
Mechanisms of development and progression of pancreatic neoplasms
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DOI: 10.1111/pin.13272
Abstract: Pancreatic ductal adenocarcinoma (PDAC) develops via dysplastic changes in the epithelia graded as low‐ and high‐grade with accumulation of molecular alterations. Constitutive activation of mitogen‐activated protein kinase (MAPK) contributed by attenuation of DUSP6 plays a… read more here.
Keywords: development; mechanisms development; progression pancreatic; development progression ... See more keywords
High expression of RAB38 promotes malignant progression of pancreatic cancer
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DOI: 10.3892/mmr.2018.9732
Abstract: Ras-Related Protein Rab-38 (RAB38), which belongs to the RAB family, is involved in the biogenesis of lysosome-related organelles and defense against certain microbial infections. However, the clinical significance and potential function of RAB38 in pancreatic… read more here.
Keywords: expression rab38; pancreatic cancer; progression pancreatic; cancer ... See more keywords
VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer
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DOI: 10.7150/ijbs.66313
Abstract: NF-κB signaling is active in more than 50% of patients with pancreatic cancer and plays an important role in promoting the progression of pancreatic cancer. Revealing the activation mechanism of NF-κB signaling is important for… read more here.
Keywords: cancer; cancer vrk2; progression pancreatic; tnf signaling ... See more keywords