Outcome of Progressive Multifocal Leukoencephalopathy Treated by Interleukin‐7
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DOI: 10.1002/ana.26307
Abstract: Restoring anti‐JC virus (JCV) immunity is the only treatment of progressive multifocal leukoencephalopathy (PML). Interleukin‐7 is a cytokine that increases number and function of T cells. We analyzed a population of PML patients who received… read more here.
Keywords: outcome progressive; treated interleukin; multifocal leukoencephalopathy; progressive multifocal ... See more keywords
Single‐center experience on progressive multifocal leukoencephalopathy (PML) cases, neuroimaging relevance, and management at West Virginia University (WVU)
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DOI: 10.1002/jmv.27804
Abstract: Progressive multifocal leukoencephalopathy (PML) is an increasingly common and rapidly fatal demyelinating infection of central nervous system caused by the highly prevalent John Cunningham (JC) virus in immunocompromised individuals belonging to all age groups and… read more here.
Keywords: pml; multifocal leukoencephalopathy; progressive multifocal; leukoencephalopathy pml ... See more keywords
Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases
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DOI: 10.1007/s00415-017-8509-9
Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare and potentially fatal condition caused by a brain infection with JC polyomavirus (JCV). PML develops almost exclusively in immunocompromised patients and has recently been associated with use of… read more here.
Keywords: fumaric acid; acid esters; progressive multifocal; multifocal leukoencephalopathy ... See more keywords
A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy
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DOI: 10.1007/s00415-018-9140-0
Abstract: ObjectiveIn the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy (PML) due to John Cunningham (JC) virus infection to identify potential prognostic factors.MethodsThe study included seven… read more here.
Keywords: prognosis; group; progressive multifocal; multifocal leukoencephalopathy ... See more keywords
BK-virus progressive multifocal leukoencephalitis in a patient with systemic lupus erythematosus
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DOI: 10.1007/s10072-018-3413-3
Abstract: Dear Editor, Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS), fatal in some cases, and JC virus (JCV) is the usual cause [1]. BK virus (BKV) is a… read more here.
Keywords: systemic lupus; patient systemic; lupus erythematosus; progressive multifocal ... See more keywords
Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML)
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DOI: 10.1007/s11481-019-09877-8
Abstract: With the advent of immunomodulatory therapies and the HIV epidemic, the impact of JC Virus (JCV) on the public health system has grown significantly due to the increased incidence of Progressive Multifocal Leukoencephalopathy (PML). Currently,… read more here.
Keywords: progressive multifocal; reactivation; multifocal leukoencephalopathy; host ... See more keywords
Progressive multifocal leukoencephalopathy in a patient with lymphoma and presumptive hyper IgE syndrome
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DOI: 10.1007/s13365-017-0536-x
Abstract: We, herein, report a 23-year-old male with a rare inherited immunodeficiency disease, hyperimmunoglobulin IgE syndrome (HIES), who developed progressive multifocal leukoencephalopathy (PML) and lymphoma simultaneously. Primary immunodeficiency of the patient has remained undiagnosed until adulthood.… read more here.
Keywords: lymphoma; immunodeficiency; progressive multifocal; ige syndrome ... See more keywords
Detectable cerebrospinal fluid JCV DNA in late-presenting HIV-positive patients: beyond progressive multifocal leukoencephalopathy?
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DOI: 10.1007/s13365-017-0549-5
Abstract: In the absence of effective prophylaxis and treatment, therapeutic options in HIV-positive patients with progressive multifocal leukoencephalopathy (PML) are limited to antiretroviral therapy: nevertheless, outcome is poor. We conducted a retrospective study (2009–2015) describing the… read more here.
Keywords: positive patients; detectable cerebrospinal; progressive multifocal; multifocal leukoencephalopathy ... See more keywords
Early reduction of the splicing factor2/alternative splicing factor: a cellular inhibitor of the JC polyomavirus in natalizumab-treated MS patients long before developing progressive multifocal leukoencephalopathy
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DOI: 10.1007/s13365-019-00793-4
Abstract: Natalizumab is effective against relapsing-remitting multiple sclerosis (MS) but increases the risk of progressive multifocal leukoencephalopathy (PML), which is caused by the activation of the JCV polyomavirus. SF2/ASF (splicing factor2/alternative splicing factor) is a potent… read more here.
Keywords: natalizumab treated; progressive multifocal; multifocal leukoencephalopathy; splicing factor2 ... See more keywords
Progressive multifocal leukoencephalopathy despite immune recovery in a HIV/HCV co-infected patient
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DOI: 10.1007/s13365-020-00848-x
Abstract: In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We… read more here.
Keywords: hcv infected; hiv; hcv; progressive multifocal ... See more keywords
T cell deficiencies as a common risk factor for drug associated progressive multifocal leukoencephalopathy.
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DOI: 10.1016/j.imbio.2018.01.002
Abstract: Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system caused by neuropathogenic prototypes of ubiquitous community-acquired JC virus (JCV). The disease became of particular concern following its association with certain therapies that… read more here.
Keywords: cell deficiencies; progressive multifocal; multifocal leukoencephalopathy; pml ... See more keywords