Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.534
Abstract: To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial (n = 487;… read more here.
Keywords: progressive multiple; multiple sclerosis; disability worsening; primary progressive ... See more keywords
Predicting onset of secondary-progressive multiple sclerosis using genetic and non-genetic factors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09850-z
Abstract: Background Predicting the transition from relapsing–remitting (RR) to secondary-progressive (SP) multiple sclerosis (MS) from early in the disease course is challenging. Objective To construct prediction models for SPMS using sociodemographic and self-reported clinical measures that… read more here.
Keywords: symptomatology; risk; progressive multiple; multiple sclerosis ... See more keywords
Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09928-8
Abstract: Gait disability in people with progressive multiple sclerosis (MS) is difficult to quantify using existing clinical tools. This study aims to identify reliable and objective gait-based biomarkers to monitor progressive multiple sclerosis (MS) in clinical… read more here.
Keywords: disability; progressive multiple; people progressive; multiple sclerosis ... See more keywords
Focal cortical atrophy following transient meningeal enhancement in a progressive multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04764-0
Abstract: Recent studies identified chronic leptomeningeal enhancement (LME) in late-acquired FLAIR sequences in secondary progressive (SP) multiple sclerosis (MS). These LMEs correlate with focal cortical inflammation and demyelination observed by pathology, which are supposed to drive… read more here.
Keywords: focal cortical; progressive multiple; multiple sclerosis; cortical atrophy ... See more keywords
Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00926-2
Abstract: High-dose biotin (HDB) is a therapy used in non-active progressive multiple sclerosis (PMS). Several reports have suggested that HDB treatment may be associated with an increased risk of relapse. We aimed to determine whether HDB… read more here.
Keywords: patients treated; high dose; progressive multiple; group ... See more keywords
Ocrelizumab for Treating Patients with Primary Progressive Multiple Sclerosis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Sign Up to like & getrecommendations! Published in 2020 at "PharmacoEconomics"
DOI: 10.1007/s40273-020-00889-4
Abstract: Ocrelizumab is indicated for relapsing remitting and primary progressive multiple sclerosis (RRMS and PPMS, respectively). In an appraisal undertaken by the National Institute for Health and Care Excellence (NICE), the company Roche presented the evidence… read more here.
Keywords: disability; progressive multiple; group; evidence ... See more keywords
Unraveling diagnostic uncertainty in transition phase from relapsing-remitting to secondary progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102211
Abstract: Abstract Background Clinicians struggle to timely diagnose secondary-progressive multiple sclerosis (SP-MS), with a ‘transition phase’ period of diagnostic uncertainty. We aimed at defining clinical markers predicting evolution to SP-MS. Methods : We reviewed 210 newly… read more here.
Keywords: transition phase; progressive multiple; diagnostic uncertainty; secondary progressive ... See more keywords
A new paraplegin mutation in a patient with primary progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102302
Abstract: Primary progressive multiple sclerosis (PPMS) presents with clinical signs of slowly progressive long tract dysfunction that can overlap with neurodegenerative disorders, such as hereditary spastic paraplegia (HSP). Herein, we present two siblings in whom we… read more here.
Keywords: progressive multiple; multiple sclerosis; primary progressive; mutation ... See more keywords
Early predictors of conversion to secondary progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103115
Abstract: BACKGROUND We conducted this study to estimated the time of conversion from relapsing-remitting MS (RRMS) to SPMS and its early predictor factors. METHODS In this retrospective study, demographic, clinical, and imaging data from MS patients… read more here.
Keywords: predictors conversion; progressive multiple; early predictors; multiple sclerosis ... See more keywords
Aberrant expression of β-catenin in CD4+ T cells isolated from primary progressive multiple sclerosis patients
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.05.057
Abstract: Primary progressive multiple sclerosis (PP-MS) is a less common progressive form of MS in approximately 10% of patients that manifest increasingly neurological disability from disease onset. To date, there are no approved treatments for the… read more here.
Keywords: expression catenin; cd4 cells; progressive multiple; catenin ... See more keywords
A case of intravascular large B-cell lymphoma of lung presenting with progressive multiple nodules on chest computed tomography
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2017.04.009
Abstract: A 71-year-old man was admitted to our hospital for dyspnea, which had worsened over a period of more than six months. He was previously diagnosed as having cryptogenic organizing pneumonia, and was treated with steroids… read more here.
Keywords: progressive multiple; intravascular large; case; large cell ... See more keywords