A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2016.11.012
Abstract: Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life. Saposins are activator proteins that promote the function of lysosomal hydrolases that mediate the degradation… read more here.
Keywords: storage; lysosomal storage; saposin deficiency; saposin ... See more keywords
Editors' note: Progressive neurodegeneration following spinal cord injury: Implications for clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Neurology"
DOI: 10.1212/wnl.0000000000006538
Abstract: In an effort to determine radiographic predictors of clinical outcome following traumatic spinal cord injury (SCI), Ziegler et al. compared early and late brain/spine MRI findings between patients with SCI and healthy controls. While early… read more here.
Keywords: note progressive; progressive neurodegeneration; editors note; cord injury ... See more keywords