Association of 758 G/A polymorphism of 3′untranslated region of prohibitin with risk of gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22182
Abstract: A polymorphic variant allele (T‐allele) in the 3′‐UTR of prohibitin (C‐to‐T at nucleotide 729) was reported to be associated with an increased risk of breast cancer. However, the association between the 3′‐UTR polymorphism of prohibitin… read more here.
Keywords: risk; gastric cancer; association; cancer ... See more keywords
Prohibitin Signaling at the Kidney Filtration Barrier.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55330-6_29
Abstract: The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and… read more here.
Keywords: kidney filtration; filtration; filtration barrier; prohibitin ... See more keywords
Characterization of mitochondrial prohibitin from Boleophthalmus pectinirostris and evaluation of its possible role in spermatogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-017-0373-0
Abstract: Prohibitin (PHB) is an evolutionarily conserved mitochondrial membrane protein. It plays a vital role in cell proteolysis, senescence, and apoptosis and is associated with spermatogenesis and sperm quality control in mammals. To study the characteristics… read more here.
Keywords: spermatogenesis; boleophthalmus pectinirostris; phb mrna; prohibitin ... See more keywords
Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01538-y
Abstract: The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal cancer cases due to somatic mutations in the adenomatous polyposis coli ( APC ) gene. Prohibitin 1 (PHB1) serves pleiotropic cellular functions with… read more here.
Keywords: prohibitin; phb1; wnt catenin; intestinal tumorigenesis ... See more keywords
Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52425-z
Abstract: The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely understood. Here, we show… read more here.
Keywords: coding genes; prohibitin; tumorigenesis; suppressor gene ... See more keywords
In situ architecture of the human prohibitin complex
Sign Up to like & getrecommendations! Published in 2024 at "Nature Cell Biology"
DOI: 10.1038/s41556-025-01620-1
Abstract: Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others1, 2. The human… read more here.
Keywords: prohibitin complex; prohibitin; biology; human prohibitin ... See more keywords
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01733-24
Abstract: ABSTRACT The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-like… read more here.
Keywords: prohibitin; candida albicans; stress; stress tolerance ... See more keywords
Identification of a Novel Interaction between Theileria Prohibitin (TaPHB-1) and Bovine RuvB-Like AAA ATPase 1
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02502-22
Abstract: Theileria annulata is an apicomplexan parasite that causes tropical theileriosis in cattle. It is the only eukaryotic pathogen able to cause cellular transformation of host cells yielding a cancer-like phenotype. ABSTRACT Theileriosis is a tick-borne… read more here.
Keywords: interaction; cell; prohibitin; bovine ... See more keywords
Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.127130
Abstract: Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the… read more here.
Keywords: promotes differentiation; neuroblastoma; prohibitin promotes; differentiation potential ... See more keywords
Characterization of Mitochondrial Prohibitin in Opsariichthys bidens and Its Potential Functions in Spermatogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137295
Abstract: Spermatogenesis is the intricate and coordinated process by which spermatogonia develop into haploid differentiated spermatozoa. Mitochondria are essential for spermatogenesis, and prohibitin (PHB) is closely associated with mitochondrial structure and function during spermatogenesis. Although PHB… read more here.
Keywords: potential functions; spermatogenesis; phb; prohibitin ... See more keywords