In situ architecture of the human prohibitin complex
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DOI: 10.1038/s41556-025-01620-1
Abstract: Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others1, 2. The human… read more here.
Keywords: prohibitin complex; prohibitin; biology; human prohibitin ... See more keywords
Cryo-EM structure of the prohibitin complex in open conformation
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2512430122
Abstract: Significance Prohibitins are implicated in diverse cellular processes and have emerged as promising therapeutic targets for treating cancers, neurodegenerative diseases, metabolic disorders, and inflammatory conditions. This study demonstrates that PHB1 and PHB2 assemble into a… read more here.
Keywords: structure prohibitin; cryo structure; prohibitin complex; complex open ... See more keywords