The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion
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DOI: 10.1038/s41598-018-27233-3
Abstract: Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These proIGF-1s have a… read more here.
Keywords: mature; production; proigf 1ea; subcellular localisation ... See more keywords