DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30494
Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder that is characterized by increasing levels of proinflammatory cytokines. The ubiquitous enzyme dipeptidyl peptidase-4 (DPP4, also known as CD26) regulates different immune disorders, although the effects of DPP4… read more here.
Keywords: synovial fibroblasts; cytokine production; rheumatoid arthritis; proinflammatory cytokine ... See more keywords
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14133
Abstract: Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are… read more here.
Keywords: production; non tir; tlr; proinflammatory cytokine ... See more keywords
Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/8907143
Abstract: We previously reported that propofol upregulated the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) via peroxisome proliferator-activated receptor gamma/liver X receptor in macrophage-derived foam cells. Here, we provide evidence that in addition… read more here.
Keywords: propofol; expression; proinflammatory cytokine; abca1 expression ... See more keywords
Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/5978271
Abstract: Psoriasis is a chronic inflammatory skin disease, and elevation of proinflammatory cytokine levels is a critical driver of the pathogenesis of psoriasis. Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play a role in… read more here.
Keywords: proinflammatory cytokine; kappab erk1; psoriatic keratinocytes; expression ... See more keywords
Enhanced Proinflammatory Cytokine Production and Immunometabolic Impairment of NK Cells Exposed to Mycobacterium tuberculosis and Cigarette Smoke
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.799276
Abstract: Aim Smoker COPD patients with chest radiological signs of prior tuberculosis (TB) showed more severe lung damage, but the mechanisms remain unclear. Emerging evidence has implicated NK cells in the pathogenesis of both COPD and… read more here.
Keywords: tuberculosis; cytokine production; proinflammatory cytokine; cytokine ... See more keywords
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.731500
Abstract: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) has been reported to be expressed in many mammalian tissues and cells. However, the functions and exact mechanisms of PHLDA1 remain unclear. In this study, we found… read more here.
Keywords: proinflammatory cytokine; phlda1; production; cytokine production ... See more keywords
Corrigendum: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.877352
Abstract: [This corrects the article DOI: 10.3389/fimmu.2022.731500.]. read more here.
Keywords: tlr4 triggered; triggered proinflammatory; phlda1 suppresses; corrigendum phlda1 ... See more keywords
Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010657
Abstract: Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs… read more here.
Keywords: proinflammatory cytokine; migraine attacks; nsaids triptans; polymorphisms proinflammatory ... See more keywords
Rheumatoid arthritis and the proinflammatory cytokine IL-17.
Sign Up to like & getrecommendations! Published in 2023 at "Folia medica"
DOI: 10.3897/folmed.65.e72448
Abstract: INTRODUCTION Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Various proinflammatory cytokines are involved in the pathogenesis of this chronic disorder. It is characterized by the presence of autoantibodies, such as rheumatoid factor… read more here.
Keywords: anti carp; proinflammatory cytokine; anti ccp; rheumatoid arthritis ... See more keywords
Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurogastroenterology and Motility"
DOI: 10.5056/jnm21002
Abstract: Irritable bowel syndrome (IBS) displays chronic abdominal pain with altered defecation. Most of the patients develop visceral hypersensitivity possibly resulting from impaired gut barrier and altered gut microbiota. We previously demonstrated that colonic hyperpermeability with… read more here.
Keywords: proinflammatory cytokine; cytokine signaling; irritable bowel; bowel syndrome ... See more keywords
Proinflammatory cytokine polarization in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2020.97904
Abstract: Subclinical inflammatory reaction is associated with non-insulin dependent diabetes. Therefore, the aim of the present study is to describe the effect of the three cytokines: interferon γ (IFN-γ), interleukin (IL)-4 and IL-5 on the development… read more here.
Keywords: diabetic patients; type diabetes; cytokine polarization; proinflammatory cytokine ... See more keywords