A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing
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DOI: 10.1210/jendso/bvac196
Abstract: Abstract Context Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of… read more here.
Keywords: somatic mutation; proinsulin processing; proinsulin levels; insulin peptide ... See more keywords