Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.09.012
Abstract: Vincristine (VCR) treatment is often associated to painful neuropathy. Its development is independent from antitumoral mechanism and involves neuroinflammation. We investigated the role of the chemokine prokineticin (PK)2 in a mouse model of VCR induced… read more here.
Keywords: neuroinflammation; emotional like; day; vincristine ... See more keywords
Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110000
Abstract: Prokineticin 1 (pk1) and prokineticin 2 (pk2) interact with two structurally related G-protein coupled receptors, prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). Cellular signalling studies show that the activated receptors can evoke Ca2+-mobilization,… read more here.
Keywords: protein subtypes; prokineticin receptors; receptor; prokineticin ... See more keywords
Identification and Characterization of a New Splicing Variant of Prokineticin 2
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020248
Abstract: Prokineticin 2 (PROK2) is a secreted bioactive peptide that regulates a variety of biological responses via two GPCRs, the prokineticin receptors (PROKRs). The aim of this study was to characterize a new alternatively spliced product… read more here.
Keywords: splicing variant; characterization new; new splicing; prokineticin ... See more keywords