Immunohistochemical localization of prolactin receptor (PRLR) to Hodgkin's and Reed-Sternberg cells of Hodgkin's lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Acta histochemica"
DOI: 10.1016/j.acthis.2020.151657
Abstract: Prolactin receptor (PRLR), a type-1 cytokine receptor, is overexpressed in a number of cancer types. It has attracted much attention for putative pro-oncogenic roles, which however, remains controversial in some malignancies. In this study, we… read more here.
Keywords: prlr hodgkin; prlr; prolactin receptor; receptor prlr ... See more keywords
Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101195
Abstract: Highlights • Systemic knockdown of the long form prolactin receptor in vivo increases survival in an aggressive, immunocompetent model of stage IV, triple negative breast cancer.• Knockdown of the long form prolactin receptor reduces Treg… read more here.
Keywords: prolactin receptor; prolactin; form prolactin; long form ... See more keywords
Association of prolactin receptor (PRLR) variants with prolactinomas
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy396
Abstract: Abstract Prolactinomas are the most frequent type of pituitary tumors, which represent 10–20% of all intracranial neoplasms in humans. Prolactinomas develop in mice lacking the prolactin receptor (PRLR), which is a member of the cytokine… read more here.
Keywords: receptor prlr; prlr; prolactin receptor; prlr variants ... See more keywords
Prolactin receptor‐mediated activation of pSTAT5 in the pregnant mouse brain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12901
Abstract: Pregnancy represents a period of remarkable adaptive physiology throughout the body, with many of these important adaptations mediated by changes in gene transcription in the brain. A marked activation of the transcription factor signal transducer… read more here.
Keywords: prolactin receptor; brain; pregnancy; pstat5 ... See more keywords
Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12908
Abstract: In addition to its critical role in lactation, the anterior pituitary hormone prolactin also influences a broad range of other physiological processes. In particular, widespread expression of prolactin receptor (Prlr) in the brain has highlighted… read more here.
Keywords: prlr; prolactin receptor; prolactin; expressing neurones ... See more keywords
Identification of prolactin receptor variants with diverse effects on receptor signalling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-22-0164
Abstract: The prolactin receptor (PRLR) signals predominantly through the JAK2-STAT5 pathway regulating multiple physiological functions relating to fertility, lactation, and metabolism. However, the molecular pathology and role of PRLR mutations and signalling are incompletely defined, with… read more here.
Keywords: prlr; prolactin receptor; prlr variants; receptor ... See more keywords
Study of Prolactin Receptor Gene (PRLR5) polymorphisms and its association with egg production in Kadaknath hens
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Animal Research"
DOI: 10.18805/ijar.v0iof.8001
Abstract: The present study was conducted to investigate the polymorphisms of prolactin receptor (PRLR5) gene and its association with egg production in Kadaknath hens. Egg production is a polygenic inheritance trait. Study was conducted on twenty… read more here.
Keywords: prolactin receptor; egg; egg production; prlr5 ... See more keywords
Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1112987
Abstract: Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds… read more here.
Keywords: prl; prolactin receptor; antibody; receptor ... See more keywords
Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13112662
Abstract: Simple Summary Unabated tumor growth, metastasis, and resistance to hormone therapy and/or to chemotherapy constitute serious impediments for combating breast cancer (BC). With the exception of targeted anti-HER2/neu therapy and combination therapies, there have been… read more here.
Keywords: cancer; small molecules; prolactin receptor; breast cancer ... See more keywords