SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12872
Abstract: Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes… read more here.
Keywords: hepatocellular carcinoma; via p53; proliferation metastasis;
circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4627
Abstract: Melanoma is an aggressive disease that is rising in incidence. Advanced melanoma is still a life‐threatening disease. CircRNAs are documented to be involved in melanoma progression. But circITCH role in melanoma remains unclear. read more here.
Keywords: circitch; cell proliferation; melanoma; proliferation metastasis ... See more keywords
A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29320
Abstract: Pancreatic ductal adenocarcinoma (PDAC), a common malignancy originated from the digestive system worldwide, has a poor clinical outcome. SPOCK1 is a widely investigated member of the Ca2+‐binding proteoglycan family and functions as an essential driver… read more here.
Keywords: proliferation metastasis; pancreatic ductal; spock1; ductal adenocarcinoma ... See more keywords
CLDN1 induces autophagy to promote proliferation and metastasis of esophageal squamous carcinoma through AMPK/STAT1/ULK1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29133
Abstract: Tight junction is a structural constitution in cell–cell adhesion and play an important role in the maintenance of permeability and integrity of normal epithelial cell barrier. The protein encoded by Claudin 1 (CLDN1), a member… read more here.
Keywords: carcinoma; cldn1; proliferation metastasis; proliferation ... See more keywords
miR-141-3p promotes proliferation and metastasis of nasopharyngeal carcinoma by targeting NME1.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2020.03.005
Abstract: PURPOSE This study aimed to investigate the expression and biological function of miR-141-3p in nasopharyngeal carcinoma (NPC) via targeting neoplasm metastasis 1 (NME1). MATERIALS AND METHODS The expression of miR-141-3p and NME1 in 5-8F, C666-1,… read more here.
Keywords: proliferation metastasis; 141 promotes; mir 141; metastasis ... See more keywords
Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104988
Abstract: Here, we report the structural optimization of a hit natural compound, 2-ME2 (2-methoxyestradiol), which exhibited inhibitory activity but low potency on tubulin polymerization, anti- angiogenesis, MCF-7 proliferation and metastasis in vitro and in vivo. A… read more here.
Keywords: methoxyestradiol; polymerization; proliferation metastasis; tubulin polymerization ... See more keywords
MiRNA-154-5p inhibits cell proliferation and metastasis by targeting PIWIL1 in glioblastoma
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DOI: 10.1016/j.brainres.2017.08.014
Abstract: MicroRNAs (miRNAs) play a critical role in glioblastoma initiation and progression. PIWIL1, a human homolog of the PIWI family, has a critical effect on glioblastoma progression. In present study, we found that the expression of… read more here.
Keywords: targeting piwil1; mir 154; glioblastoma; proliferation metastasis ... See more keywords
miR‐190 promotes HCC proliferation and metastasis by targeting PHLPP1
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DOI: 10.1016/j.yexcr.2018.08.008
Abstract: ABSTRACT miRNAs regulate gene expression and enable clinicians to distinguish between benign and malignant tissues in cancers. PH domain leucine‐rich repeat‐containing protein phosphatase 1 (PHLPP1) is known to be a tumour suppressor. A lentiviral overexpression… read more here.
Keywords: proliferation metastasis; expression; mir 190; hcc proliferation ... See more keywords
Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
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DOI: 10.1038/s41598-018-20459-1
Abstract: Simulated microgravity (SMG) was reported to affect tumor cell proliferation and metastasis. However, the underlying mechanism is elusive. In this study, we demonstrate that clinostat-modelled SMG reduces BL6-10 melanoma cell proliferation, adhesion and invasiveness in… read more here.
Keywords: melanoma cell; cell proliferation; cell; proliferation metastasis ... See more keywords
CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p
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DOI: 10.1080/15384101.2021.2014738
Abstract: ABSTRACT Increasing evidence reveals that circular RNAs (circRNAs) regulate multiple biological functions in glioma. Previously, several reports have illustrated that circFAM53B contributes to cancer development. However, the functions and mechanisms of circFAM53B in glioma remain… read more here.
Keywords: pi3k akt; proliferation metastasis; circfam53b; glioma ... See more keywords
Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a
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DOI: 10.1080/21655979.2022.2036898
Abstract: ABSTRACT Cervical cancer is a malignant tumor that severely threatens female health. Recently, more and more studies indicated that circRNA could function as a tumor activator or suppressor in cervical cell development. Therefore, we aimed… read more here.
Keywords: cervical cancer; mir 449a; proliferation metastasis; circcdk6 ... See more keywords